Residual radiation-induced damage to the kidney of the pig as assayed by retreatment
| Autor: | M. Rezvani, T. Bywaters, S.J. Golding, John W. Hopewell, M.E.C. Robbins |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Kidney
medicine.medical_specialty Radiobiology Radiological and Ultrasound Technology urogenital system business.industry Urology Renal function Large white Radiation induced Effective renal plasma flow medicine.anatomical_structure medicine Radiology Nuclear Medicine and imaging Both kidneys X ray irradiation Nuclear medicine business |
| Zdroj: | International Journal of Radiation Biology. 60:917-928 |
| ISSN: | 0955-3002 |
| DOI: | 10.3109/09553009109169319 |
| Popis: | SummaryThe effect of re-irradiation on the previously irradiated kidney was studied in the Large White female pig. Both kidneys of 14-week-old pigs were initially irradiated with a single dose of 3–7 Gy of 250 kV X-rays. The individual kidney glomerular filtration rate (GFR), effective renal plasma flow (ERPF), and the haematocrit (Hct) were serially measured up to 24 weeks after X-irradiation. Doses of 3 and 5 Gy of X-rays had little effect on the GFR. However, 7 Gy of X-rays caused a marked decline in the GFR up to 12 weeks after irradiation; the GFR then began to recover. A similar pattern of response was seen in the ERPF. In contrast, the Hct was reduced in all pigs 4 weeks after X-irradiation. The extent of the decline and subsequent recovery 24 weeks after irradiation appeared to be related to dose. Twenty-four weeks after X-irradiation both kidneys were re-irradiated with a single dose of 7·9 Gy of 60Co γ-rays; both kidneys of four age-matched control pigs which had not previously received X-irradi... |
| Databáze: | OpenAIRE |
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