Strain difference in the susceptibility to clofibrate in male rats

Autor:	Takashi Yamoto, Naochika Matsunuma, Sunao Manabe, Nobuhiro Miyakoshi, Yoshihiko Ohashi, Takashi Makita
Rok vydání:	1996
Předmět:	medicine.medical_specialty Clofibrate Cytochrome P450 Biology Peroxisome Strain difference Pathology and Forensic Medicine Sprague dawley Endocrinology Biochemistry Catalase Physiology (medical) Internal medicine Male rats medicine biology.protein Carnitine acetyltransferase activity medicine.drug
Zdroj:	Pathophysiology. 3:65-72
ISSN:	0928-4680
DOI:	10.1016/0928-4680(95)00056-9
Popis:	Difference among strains in the susceptibility to clofibrate in male rats was clarified. Males of three rat strains (F344, Sprague Dawley (SD), and Wistar Lewis) were treated with clofibrate mixed in the diet for 14 days. Both biochemical analysis (measurement of cytochrome P450 content, alkoxycoumarin O-dealkylation, carnitine acetyltransferase activity, peroxisomal β-oxidation, and catalase activity) and morphological analysis (electron microscopy and morphometry of peroxisomes) proved the strain difference. Although the changes caused by clofibrate administration were detected in all strains, the degree of these changes was variable among different strains. The most responsive rat strain was Wistar Lewis, while SD was the least responsive.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d476b56b03784f2d899d1bd71c5f9134 https://doi.org/10.1016/0928-4680(95)00056-9 Zobrazit plný text záznamu Full Text from ScienceDirect