Effects of Vitex agnus-castus extract on the secretory function of pituitary-gonadal axis and pregnancy rate in patients with premature ovarian aging (POA)
| Autor: | Maryam Nemati, Batool Hossein-Rashidi |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
endocrine system medicine.medical_specialty Pregnancy 030219 obstetrics & reproductive medicine biology media_common.quotation_subject Letrozole Vitex Pituitary gonadal axis biology.organism_classification medicine.disease 03 medical and health sciences Pregnancy rate 030104 developmental biology 0302 clinical medicine Endocrinology Complementary and alternative medicine Internal medicine Follicular phase medicine Ovulation Menstrual cycle media_common medicine.drug |
| Zdroj: | Journal of Herbal Medicine. 10:24-30 |
| ISSN: | 2210-8033 |
| Popis: | Objective To evaluate the beneficial effects of Vitex agnus-castus (VAC) extract as a fertility-enhancing herb, on the secretory functions of pituitary-gonadal axis and reproductive potential of premature ovarian ageing (POA) patients. The authors introduced a novel treatment for increasing the rate of pregnancy in women with POA. Material and methods Sixty one POA patients were divided into a control and experimental group. The women in the control group received 5 mg letrozole from day 3 of the menstrual cycle for a total of 4 days. In addition to similar treatment with letrozole in the control group, 32 patients in the experimental group received 40 drops of VAC for 4 months throughout the follicular phase. Ovulation days, endometrial thickness, estradiol levels on ovulation time, serum concentrations of FSH, AMH, and estradiol, as well as the average time of serum positive s-HCG test, chemical and clinical pregnancy rates were investigated in both groups during 4 months of study. Results Despite an increase in AMH levels after treatment in both groups, serum concentrations of FSH and estradiol were significantly decreased in patients receiving VAC. Treatment with VAC significantly decreased estradiol levels on ovulation day and the average time of serum positive s-HCG test. Ovulation day, endometrial thickness, chemical and clinical pregnancy rates in the experimental group were significantly higher than the control group throughout course of treatment. Conclusion VAC extract as a fertility-promoting plant appears to be a safe and effective herb for medicinal applications in women with POA when used within the established dosage guidelines. |
| Databáze: | OpenAIRE |
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