Doxorubicin-Conjugated Platinum Theranostic Nanoparticles Induce Apoptosis via Inhibition of a Cell Survival (PI3K/AKT) Signaling Pathway in Human Breast Cancer Cells

Autor:	Mohamed Sultan Mohamed Jabir, Vinita Manimaran Nadar, Subramanian Tamil Selvan, Ponnuchamy Kumar, Balázs Gulyás, Selvambigai Manivannan, Srinivasan Pappu, Pitchan Arul Prakash, Parasuraman Padmanabhan, Rajiu Venkatesan, Puja Patel, Devan Umapathy, Velanganni Antony Joseph Arokiyam
Rok vydání:	2020
Předmět:	Chemistry Conjugated system Platinum nanoparticles medicine.disease Breast cancer Apoptosis Cancer cell polycyclic compounds medicine Cancer research General Materials Science Doxorubicin Protein kinase B PI3K/AKT/mTOR pathway medicine.drug
Zdroj:	ACS Applied Nano Materials. 4:198-210
ISSN:	2574-0970
Popis:	Herein, we report facile theranostic platinum nanoparticles (PtNPs) conjugated to an anticancer drug, doxorubicin (DOX), in unraveling the inhibition of a cell survival PI3K/AKT (phosphatidylinosit...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d4640bd07129b06f6453adc15925d8f6 https://doi.org/10.1021/acsanm.0c02521 Zobrazit plný text záznamu