Drug repositioning of benzimidazole anthelmintics in the treatment of cryptococcosis: a review
| Autor: | Karen L. Lang, Gabriella Freitas Ferreira, Emanuel Almeida Moreira de Oliveira |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Drug
medicine.medical_specialty biology Chemistry media_common.quotation_subject Organic Chemistry Mebendazole Cryptococcus Flubendazole Disease biology.organism_classification medicine.disease Drug repositioning chemistry.chemical_compound Cryptococcosis medicine Anthelmintic General Pharmacology Toxicology and Pharmaceutics Intensive care medicine medicine.drug media_common |
| Zdroj: | Medicinal Chemistry Research. 31:26-39 |
| ISSN: | 1554-8120 1054-2523 |
| Popis: | Cryptococcosis is a systemic mycosis caused by pathogenic yeasts of the Cryptococcus genus and the second biggest cause of morbidity and mortality in individuals with AIDS. Cryptococcal meningitis is the most severe form of the disease, with high lethality rates. Currently, only three antifungals drugs are approved for the treatment of cryptococcosis, which present high toxicity, low efficacy, high costs, and limited availability in several countries. The need for new antifungals for the treatment of systemic mycosis is clear; however, drug research and development is costly and time-consuming. Drug repositioning is a strategy that has been promising for the development of new therapeutic alternatives for diseases that suffer from scarce therapeutic resources, such as cryptococcosis, as it presents a considerable reduction in costs, risks, and research time. Some drug candidates for repositioning share structural similarities with each other that may reflect a scaffold in the discovery of new anticryptococcal agents. The anthelmintics drugs albendazole, flubendazole, mebendazole, and fenbendazole showed potent in vitro antifungal activity apparently related to the benzimidazole scaffold present in these drugs. Thus, this non-systematic review discusses recent data about benzimidazole anthelmintic drugs as promising candidates for repositioning in the treatment of cryptococcosis. |
| Databáze: | OpenAIRE |
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