RELATIVE EFFECT OF VITAMIN D AND PARATHYROID EXTRACT ON PLASMA CALCIUM AND CITRIC ACID OF NORMAL AND THYROPARATHYROIDECTOMIZED DOGS1

Autor:	Joseph R. Elliott, Smith Freeman
Rok vydání:	1956
Předmět:	Calcium metabolism medicine.medical_specialty Tetany chemistry.chemical_element Calcium chemistry.chemical_compound Endocrinology chemistry Internal medicine Blood plasma Sodium citrate medicine Vitamin D and neurology Fluoroacetate medicine.symptom Citric acid
Zdroj:	Endocrinology. 59:196-200
ISSN:	1945-7170 0013-7227
DOI:	10.1210/endo-59-2-196
Popis:	HYPERCALCEMIA resulting from calcium mobilization may be accompanied by some elevation of the plasma concentration of citrate. Hypocalcemia is usually accompanied by a reduced plasma citrate value in the parathyroidectomized animal (1). Hypercalcemia produced by calcium chloride infusion for a short time (6 hours) did not elevate the citrate concentration (2). Hypercitricemia produced by the infusion of sodium citrate, nephrectomy or fluoroacetate administration is accompanied by an elevation of plasma concentration of calcium. There appears to be a relation between the serum concentration of calcium and citric acid. It is not apparent whether the degree of hypercitricemia is independent of the amount or mechanism of an endogenous hypercalcemia. It seems important to establish this point in determining whether or not the relation of calcium and citric acid is entirely dependent upon chemical affinity or is related in some other sense depending upon bodily mechanisms.
Databáze:	OpenAIRE
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