Role of Astrocytes in Major Neuropsychiatric Disorders
| Autor: | Rawan Alnafisah, Zhexing Wen, Sinead M. O’Donovan, Robert E. McCullumsmith, Abdul-Rizaq Hamoud, Rammohan Shukla, Xiaolu Zhang |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Postmortem studies Neurology business.industry Central nervous system General Medicine medicine.disease Biochemistry 03 medical and health sciences Cellular and Molecular Neuroscience 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Schizophrenia mental disorders medicine Major depressive disorder Neurochemistry Bipolar disorder business Neuroscience 030217 neurology & neurosurgery Astrocyte |
| Zdroj: | Neurochemical Research. 46:2715-2730 |
| ISSN: | 1573-6903 0364-3190 |
| Popis: | Astrocytes are the primary homeostatic cells of the central nervous system, essential for normal neuronal development and function, metabolism and response to injury and inflammation. Here, we review postmortem studies examining changes in astrocytes in subjects diagnosed with the neuropsychiatric disorders schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BPD). We discuss the astrocyte-related changes described in the brain in these disorders and the potential effects of psychotropic medication on these findings. Finally, we describe emerging tools that can be used to study the role of astrocytes in neuropsychiatric illness. |
| Databáze: | OpenAIRE |
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