Temporomandibular Joint Involvement in Association With Quality of Life, Disability, and High Disease Activity in Juvenile Idiopathic Arthritis
| Autor: | Kevin J. Murray, Donato De Angelis, Joyce Davidson, Fabrizia Corona, Elena Palmisani, Paula Frid, Berit Flatø, Nicolino Ruperto, Denise Pires Marafon, Ellen Nordal, Francesca Bovis, Rotraud K. Saurenmann, Tore A. Larheim, Angelo Ravelli, Sheila Knupp Feitosa de Oliveira, Angela Pistorio, Francesco Zulian, Pekka Lahdenne, Gabriella Giancane, Marite Rygg, Michel H. Steenks, Gabriele Simonini, Alberto Martini, Eileen Baildam, Helen E. Foster |
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| Rok vydání: | 2017 |
| Předmět: |
musculoskeletal diseases
030203 arthritis & rheumatology medicine.medical_specialty Physical disability Cross-sectional study business.industry Arthritis 030206 dentistry Odds ratio medicine.disease 03 medical and health sciences Juvenile Arthritis Disease Activity Score 0302 clinical medicine stomatognathic system Rheumatology Quality of life Internal medicine Severity of illness Cohort medicine Physical therapy business |
| Zdroj: | Arthritis Care & Research. 69:677-686 |
| ISSN: | 2151-464X |
| Popis: | Objectives. To evaluate the demographic, disease activity, disability and health-related quality of life (HRQoL) differences between children with juvenile idiopathic arthritis (JIA) and their healthy peers, and between children with JIA with and without clinical temporomandibular joint (TMJ) involvement and its determinants. Methods. This study is based on a cross-sectional cohort of 3343 children with JIA and 3409 healthy peers, enrolled in the Pediatric Rheumatology International Trials Organisation (PRINTO) health-related quality of life (HRQoL) study or in the methotrexate trial. Potential determinants of TMJ involvement included demographic, disease activity, disability and HRQoL measures selected through univariate and multivariable logistic regression. Results. Clinical TMJ involvement was observed in 387/3343 (11.6%) JIA children. Children with TMJ involvement, compared to those without, more often had polyarticular disease course (95% versus 70%), higher Juvenile Arthritis Disease Activity Score (JADAS) (odds ratio (OR) 4.6), more disability and lower HRQoL. Children with TMJ involvement experienced clearly more disability and lower HRQoL compared to their healthy peers. The multivariable analysis, showed that cervical spine involvement (OR 4.6), disease duration > 4.4 years (OR 2.8), and having more disability (Childhood Health Assessment Questionnaire Disability Index >0.625) (OR 1.6) were the most important determinants for TMJ involvement. Conclusion. Clinical TMJ involvement in JIA is associated with higher disease activity, higher disability and impaired HRQoL. Our findings indicate the need for dedicated clinical and imaging evaluation of TMJ arthritis especially in children with cervical spine involvement, polyarticular course and longer disease duration. This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
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