Acute lung injury and repair induced by single exposure of Aspergillus fumigatus in immunocompetent mice
| Autor: | Mauro M. Teixeira, Vanessa Pinho, Graziele Letícia N. Lima, Frederico Marianetti Soriani, Milene Alvarenga Rachid, Daniele G. Souza, Remo Castro Russo, Matheus Silvério Mattos, Jéssica Am Souza, Lucas Kraemer, Lirlândia P. Sousa, Nathália Lso Malacco, Aline C. Mendes |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Aspergillus biology business.industry 030106 microbiology Lung injury biology.organism_classification medicine.disease Microbiology Aspergillus fumigatus Proinflammatory cytokine 03 medical and health sciences Pneumonia 030104 developmental biology Apoptosis Immunology medicine Nasal administration skin and connective tissue diseases Efferocytosis business |
| Zdroj: | Future Microbiology. 14:1511-1525 |
| ISSN: | 1746-0921 1746-0913 |
| DOI: | 10.2217/fmb-2019-0214 |
| Popis: | Aim: Characterize the course of acute Aspergillus fumigatus lung infection in immunocompetent mice, investigating the immunological, pathological and tissue functional modifications. Materials & methods: C57BL/6 mice were intranasally infected with A. fumigatus conidia and euthanized to access inflammatory parameters. Results: Mice infected with A. fumigatus showed an inoculum-dependent lethality and body weight loss. An intense proinflammatory cytokine release, neutrophil infiltrate and pulmonary dysfunction was also observed in the early phase of infection. In the late phase of infection, proresolving mediators release, apoptosis and efferocytosis increased and lung tissue architecture is restored. Conclusion: Our study characterized an immunocompetent model of acute pulmonary Aspergillus infection in mice and opened an array of possibilities for investigations on interactions of A. fumigatus with host-immune system. |
| Databáze: | OpenAIRE |
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