Risk Factors for In-hospital Progression of Ordinary COVID-19 in Wuhan, China: A Retrospective Cohort Study

Autor: Ling Tong, Zhang Yong, Linlin Zhao, Jing Liu, Fan Zhou, Ying Xiong, Zhenhua Lv, Airong Yu, Yan Zhao, Yingjun Tan, Haichao Liu, Xing Fan, Chengrui Zhou, Ying Zhang
Rok vydání: 2020
Předmět:
DOI: 10.21203/rs.3.rs-23094/v1
Popis: Objective: To describe the clinical characteristics and outcomes of ordinary COVID-19 when admitted, to describe how these patients were treated and risk factors for in-hospital progression.Methods: In this retrospective study, we included 291 adult patients diagnosed as ordinary COVID-19 on admission who had been discharged or had died between Jan 20, 2020 and Mar 16, 2020 from General Hospital of Central Theatre Command (Wuhan, China).Results: Of the 291 patients diagnosed as ordinary COVID-19 when admitted, 65 (22.34%) had been recorded COVID-19 progressing at least once, and 226 (77.66%) had been recorded COVID-19 improving during hospitalization. The median time from admission to disease progressed was 5.0 days (2.0-7.0). Multivariable regression showed increasing odds of in-hospital progression associated with male (odds ratio 2.333, 95% CI 1.135-4.395; P=0.020), preexisting cardiovascular diseases (2.433, 1.044-5.671; P=0.039), and lymphopenia (3.482, 1.783-6.799; PConclusions: The potential risk factors of male, preexisting cardiovascular disease, lymphopenia, elevated IL-6, and lactate dehydrogenase, d-dimer could help clinicians to identify in-hospital progression among ordinary COVID-19 at early stage to optimize medical treatment.
Databáze: OpenAIRE