Impact of Multiplicity of Plasmodium falciparum Infection on Clinical Disease in Malawi
| Autor: | Miriam K. Laufer, Dominique Earland, Andrea G. Buchwald, Milius Damson, Terrie E. Taylor, Alick Sixpence, Mabvuto Chimenya, Karl B. Seydel, Don P. Mathanga |
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| Rok vydání: | 2019 |
| Předmět: |
biology
business.industry viruses 030231 tropical medicine Repeated measures design Plasmodium falciparum Disease biochemical phenomena metabolism and nutrition medicine.disease biology.organism_classification Asymptomatic 03 medical and health sciences 0302 clinical medicine Infectious Diseases Multiplicity of infection Virology Immunology Genotype medicine Parasitology medicine.symptom Risk factor business Malaria |
| Zdroj: | The American Journal of Tropical Medicine and Hygiene. 101:412-415 |
| ISSN: | 1476-1645 0002-9637 |
| DOI: | 10.4269/ajtmh.19-0093 |
| Popis: | Multiplicity of infection (MOI), the number of unique Plasmodium falciparum parasite genotypes found in one infected individual, may contribute to the development of clinical malaria disease. However, the independent contribution of MOI and parasite density to clinical disease has not been well characterized. We conducted a two-year longitudinal cohort study of adults and children in a high-transmission setting in Malawi to test the hypothesis that increased MOI was independently associated with clinical disease, after accounting for parasite density. Of 1,062 episodes of infection, 477 (44.9%) were associated with symptoms. After controlling for repeated measures within an individual, key demographic factors, and parasite density, there was no association between MOI and clinical disease (OR = 1.02, 95% CI: 0.70-1.51). Although the limited ability to discern MOI in low-density asymptomatic infections may have impacted our results, we conclude that MOI is not an independent risk factor for clinical disease. |
| Databáze: | OpenAIRE |
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