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The aim of study was to assess the prevalence of densitometric disorders and deficiencies of vitamin D3 in children vertically HIV-infected, treated with cART. In 34 children vertically HIV-infected aged 10-16 years (mean 13 years), receiving cART ≥ 5, bone densitometry and the titer of 25-OHD3 was done. We analyzed at the time of diagnosis of HIV infection and at the time of the study: age, clinical and immunological classification, the length, effectiveness of cART, the lowest immunological classification. 15/34 (44%) children had abnormal dual-energy X-ray absorptiometry examination (DEXA) of the lumbar aged-matched mean Z-score -2.1 (range -1.2 to -3.5), of which 8 also had abnormal DEXA whole spine aged-matched mean Z-score -1.6 (range -1.1 to - 2.2). Level of 25-OHD3 was abnormal (< 20 ng/ml) in 29/34 (85%), in 7 of them the level was very low (< 4.0 ng /ml). 4/5 children with normal values of 25-OHD3 parallel had correct densitometry; 1/5 with a normal value of 25-OHD3 had significant abnormalities of bone density, visible in radiographs of the hand. Clinical classification at diagnosis was: N/A in 17, B in 12, C in 5 and immunological classification: 1 in 11, 2 in 9, 3 in 13 cases. The lowest classification was AIDS in 9 children, 15 had moderate signs of infection, and 10 mild signs; deep immune deficiency occurred in 17 children, 15 had moderate and 2 have never had immunodeficiency. The regimens based on PI received 9 children, NNTRI -6, all 3 classes received 19. At the time of the study 31 children were successfully treated, 32 had no immunodeficiency, two had moderate deficiency. 32 children were qualified to N/A group, one was in the classification of B and one in C. All children unsuccessfully treated (3) had low levels of 25-OHD3. In a significant percentage of older children receiving antiretroviral treatment ≥ 5 years, had abnormal results of densytometry examination. There was no correlation between age, duration of the cART, the severity of the clinical, immunological classification, viral load and bone density disorders. Level of 25-OHD3 was abnormal in the majority of children. Disorders were also found in children successfully treated. (Published: 11 November 2012) Citation: Abstracts of the Eleventh International Congress on Drug Therapy in HIV Infection Marczynska M et al. Journal of the International AIDS Society 2012, 15 (Suppl 4):18322 http://www.jiasociety.org/index.php/jias/article/view/18322 | http://dx.doi.org/10.7448/IAS.15.6.18322 |
