Synthesis of Metabolites of the Prodrug 2,5-Bis(4-O-methoxyamidinophenyl)furan

Autor:	Mariappan Anbazhagan, David W. Boykin, James Edwin Hall, Janelle Y. Saulter
Rok vydání:	2003
Předmět:	Pharmacology chemistry.chemical_compound chemistry Metabolite Furan Heck reaction Organic Chemistry Organic chemistry Prodrug Analytical Chemistry Stille reaction
Zdroj:	HETEROCYCLES. 60:1133
ISSN:	0385-5414
DOI:	10.3987/com-03-9716
Popis:	The synthesis of three metabolites of the prodrug 2,5-bis (4-O-methoxyamidinophenyl)furan (1), 2-(4-hydroxyamidinophenyL)-5-(4-methoxyamidinophenyl)furan (M1) 2-(4-amidinophenyl)-5-(4-ethoxyamidinophenyl)-furan (M3) and 2-(4-amidinophenyl)- 5-(4-hydroxyamidinophenyl) furan (M4), is reported. The key step in each of the syntheses involves the Heck reaction.
Databáze:	OpenAIRE
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