СРАВНИТЕЛЬНОЕ ИССЛЕДОВАНИЕ МОЗЖЕЧКОВОГО И ГИПОТАЛАМИЧЕСКОГО ТОРМОЖЕНИЯ АКТИВНОСТИ НЕЙРОНОВ ЯДРА ДЕЙТЕРСА В НОРМЕ И В УСЛОВИЯХ ОДНОСТОРОННЕЙ ЛАБИРИНТЭКТОМИИ У КРЫС
| Autor: | Hambardzumyan L, E., Khalaji N, Manukyan L, P., Chavushyan V, A., Sarkissian J, S., Sargsian V, H. |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
односторонняя лабиринтэктомия
paraventricular and supraoptical nuclei of hypothalamus высокочастотная стимуляция the high-frequency stimulation кора мозжечка нейроны латерального вестибулярного ядра Дейтерса паравентрикулярное и супраоптическое ядра гипоталамуса unilateral labyrinthectomy cerebellar cortex neurons of Deiters’ lateral vestibular nucleus |
| DOI: | 10.18454/asy.2011.14.654 |
| Popis: | In intact rats special mathematical analysis of impulse activity of the Deiters’ lateral vestibular nucleus (LVN) neurons to high frequency stimulation (HFS) of the cerebellar anterior lobe (lobules I-V) revealed predominantly inhibitory manifestations (tetanic depression – TD), better expressed at 100 Hz. At 3d day after unilateral labyrinthectomy (UL) already to HFS 50 Hz of cerebellum occurred TD in neurons of LVN, similar to that at 100 Hz in intact rats, but twice more pronounced and as a rule accompanied by posttetanic inhibitory and excitatory effects (posttetanic depression – PTD and potentiation – PTP). In both cases, occasionally was detected tetanic potentiation (TP) with stabilization of activity in the norm, which after the UL was followed by PTP. In other words during UL neuronal activity of LVN to HFS of cerebellum was characterized by deepening of inhibition and joining to tetanic effects the posttetanic manifestations of activity, indicating on compensatory activation of inhibitory processes. The presence of almost equally represented excitatory and inhibitory influences realizing by HFS of hypothalamic paraventricular and supraoptical nuclei at LVN level, indicates their regulatory impact. It is not excluded that in respect of autonomic and motor manifestations of the multiple functioning of the vestibular complex, the mentioned hypothalamic regulation controls predominantly inhibitory output of the cerebellar cortex at the level of LVN. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|