Synthesis and Hypnotic Activity of New 4-Thiazolidinone and 2-Thioxo-4,5-imidazolidinedione Derivatives

Autor:	Gültaze Çapan, N. Ergenc, Nur Sibel Günay, Engin Kendi, Sumru Özkırımlı, Süheyla Özbey, Mehmet Güngör
Rok vydání:	1999
Předmět:	Pentobarbital Stereochemistry medicine.drug_class Chloroacetic acid Pharmaceutical Science Biological activity Chemical synthesis Hypnotic chemistry.chemical_compound chemistry Oxalyl chloride Drug Discovery medicine 4-thiazolidinone Semicarbazone medicine.drug
Zdroj:	Archiv der Pharmazie. 332:343-347
ISSN:	1521-4184 0365-6233
DOI:	10.1002/(sici)1521-4184(199910)332:10<343::aid-ardp343>3.0.co;2-0
Popis:	Conveniently accessible 4-[(2-(3,4-dimethoxyphenyl)ethyl]-3-thiosemicarbazide (2) was converted to new 1-substituted benzylidene/furfurylidene-4- [2-(3,4-dimethoxyphenyl)ethyl]-3-thiosemicarbazides (3) which furnished 2-(substituted benzylidene/furfurylidene) hydrazono-3-[2-(3,4-dimethoxyphenyl)ethyl]thiazolidin-4-ones (4) and 1-(substituted benzylidene/furfurylidene)-amino -3-[2-(3,4-dimethoxyphenyl)ethyl]-2-thioxo-4,5-imidazolidinedio nes (5) on reaction with chloroacetic acid and oxalyl chloride, respectively. The structure of 5 was confirmed by X-ray diffraction studies performed on 5a. 4 and 5 were evaluated for their potentiating effects on pentobarbital induced hypnosis. Most of the compounds caused remarkable increases in pentobarbital sleeping time.
Databáze:	OpenAIRE
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