ChemInform Abstract: Synthesis of Protected Derivatives of 3-Pyrrolylalanine

Autor:	Jody Beecher, David A. Tirrell
Rok vydání:	2010
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Double bond chemistry General Medicine Medicinal chemistry Isopropyl Pyrrole derivatives Pyrrole Formylation
Zdroj:	ChemInform. 29
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.199834142
Popis:	Protected derivatives of 3-pyrrolylalanine (3-PA) have been synthesized starting with N-tri(isopropyl)silylpyrrole. Following formylation and Boc protection, treatment with (±)-N-(benzyloxycarbonyl)-α-phosphonoglycine trimethyl ester provided a fully protected dehydro-3-pyrrolylalanine. Reduction of the double bond and removal of the methyl ester groups yielded 3-PA protected at the α- and pyrrole nitrogens. 3-PA is only transiently stable following N-deprotection.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d41514a05be6b4868545656a1256b31c https://doi.org/10.1002/chin.199834142 Zobrazit plný text záznamu Plný text