Synthesis and Antituberculotic Properties of Some Substituted Pyrazinecarbothioamides

Autor:	Antonín Lyčka, Želmíra Odlerová, Vladimír Buchta, Martin Doležal, Jiří Hartl
Rok vydání:	1996
Předmět:	chemistry.chemical_classification Susceptibility testing biology Chemistry medicine.drug_class Stereochemistry General Chemistry biology.organism_classification Antimycobacterial Mycobacterium tuberculosis Elemental analysis Proton NMR medicine Moiety Thioamide
Zdroj:	Collection of Czechoslovak Chemical Communications. 61:1102-1108
ISSN:	1212-6950 0010-0765
DOI:	10.1135/cccc19961102
Popis:	A series of N-substituted 3-amino-5-thiocarbamoyl-2-pyrazinecarboxamides was prepared. The structure of compounds was confirmed by elemental analysis, IR and 1H NMR spectra. The results of in vitro antifugal and antimycobacterial susceptibility testing shown no activity against pathogenic fungi and some effect on mycobacteria. The highest antituberculotic activity (MIC within 25-50 mg ml-1) against Mycobacterium tuberculosis and other mycobacterial strains in this series was shown by 3-(3-hydroxyphenylamino)-5-thiocarbamoyl-2-pyrazinecarboxamide. The antituberculotic activity of these compounds is mostly influenced by the presence of the thioamide moiety.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d40e8c5ae9bcfd67819d5227546edd23 https://doi.org/10.1135/cccc19961102 Zobrazit plný text záznamu