Design, synthesis and X-ray crystallographic studies of [7.3.1] and [8.3.1] macrocyclic FKBP-12 ligands

Autor: Susumo Katoh, J. Ernest Villafranca, Cristina T. Lewis, Michael Imbacuan, Richard E. Showalter, Babine Robert E, Littlefield Ethel S, Judy V. French, Hans E. Parge, Ted M. Bleckman, John H. Tatlock, L. A. K. Pelletier
Rok vydání: 1996
Předmět:
Zdroj: Bioorganic & Medicinal Chemistry Letters. 6:385-390
ISSN: 0960-894X
DOI: 10.1016/0960-894x(96)00032-7
Popis: The design, synthesis, and structure activity relationships of a series of novel macrocyclic FKBP-12 ligands 1 are reported. The crystal structure of the complex between 7 and human FKBP-12 is reported and some SAR results are discussed based on this complex.
Databáze: OpenAIRE