No add-on effects of Unilateral and Bilateral Transcranial Direct Current Stimulation on Fine Motor Skill Training Outcome in Chronic Stroke. A Randomized Controlled Trial
| Autor: | Robert Lindenberg, Ulrike Grittner, Robert Darkow, Benedikt Taud, Agnes Flöel, Jasmin Wevers, Marcus Meinzer, Dorothee Höfflin |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
genetic structures Transcranial direct-current stimulation business.industry medicine.medical_treatment education Fine motor skill behavioral disciplines and activities law.invention Physical medicine and rehabilitation Text mining Randomized controlled trial law Training outcome medicine business Chronic stroke psychological phenomena and processes |
| Popis: | Background: Transcranial direct current stimulation (tDCS) may improve motor recovery after stroke. This study investigated if uni- and bihemispheric tDCS of the motor cortex can enhances fine motor training outcome and transfer to clinical assessments of upper motor function. Methods: In a randomized, double-blinded, sham-controlled trial, forty chronic stroke patients underwent five days of fine motor skill training of the paretic hand with either unilateral or bilateral (N=15/group) or placebo tDCS (N=10). Immediate and long-term (three months) effects on training outcome and motor recovery (Upper Extremity Fugl-Meyer, UE-FM, Wolf Motor Function Test, WMFT) were investigated. Results: Trained task performance significantly improved independently of tDCS in a curvilinear fashion. Anodal, but not dual tDCS resulted in a steeper learning curve on the UE-FM. Neither training nor combined training-tDCS improved WMFT performance.Conclusions: Fine motor skill training can facilitate recovery of upper extremity function. Minimal add-on effects of tDCS were observed.Clinical Trial Registration-URL: NCT01969097 retrospectively registered on 25/10/2013. |
| Databáze: | OpenAIRE |
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