Abstract C026: Lack of HER4 signaling predicts poor prognosis among triple-negative breast cancer patients of African descent: A multi-institutional study

Autor: Guanhao Wei, Remus Osan, Uma Krishnamurti, Andrew R. Green, Nikita Wright, A O J Agboola, Emad A. Rakha, Lauren E. McCullough, Ian O. Ellis, Padmashree C.G. Rida, Xiaoxian Li, Chaeyun Lee, Ritu Aneja, Bikram Sahoo
Rok vydání: 2020
Předmět:
Zdroj: Cancer Epidemiology, Biomarkers & Prevention. 29:C026-C026
ISSN: 1538-7755
1055-9965
Popis: Triple-negative breast cancer (TNBC) disproportionately affects African-American (AA) women. Literature underscores that women from West Africa exhibit higher TNBC incidence and mortality rates than AA women. Distinctions in inherent tumor biology between the races have been speculated to underlie this global disparate burden. We conducted a multi-institutional study in which we analyzed differences in expression of BC-related immunohistochemical biomarkers between self-reported European, EA, AA, and African TNBC patients treated at Nottingham University in Nottingham, UK, Emory University in Atlanta, GA, and Olabisi Onabanjo University Teaching Hospital in Sagamu, Nigeria, respectively. We discovered highly significant differences in expression of the members of the HER family, HER1/EGFR, HER3 and HER4, between the racial groups (p Citation Format: Nikita Wright, Chaeyun Lee, Uma Krishnamurti, Xiaoxian Li, Bikram Sahoo, Andrew Green, Ian Ellis, Ayodeji Agboola, Guanhao Wei, Lauren McCullough, Emad Rakha, Padmashree C.G. Rida, Remus Osan, Ritu Aneja. Lack of HER4 signaling predicts poor prognosis among triple-negative breast cancer patients of African descent: A multi-institutional study [abstract]. In: Proceedings of the Eleventh AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2018 Nov 2-5; New Orleans, LA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl):Abstract nr C026.
Databáze: OpenAIRE
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