Self-administered Topical 5% Imiquimod Cream for External Anogenital Warts
| Autor: | Kathy A. Schmitt, L. J. Eron, Mary L. Owens, David Baker, Andrina J. Hougham, Alex Ferenczy, Libby Edwards, Terry L. Fox |
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| Rok vydání: | 1998 |
| Předmět: |
Sexually transmitted disease
medicine.medical_specialty Randomization business.industry virus diseases Imiquimod Dermatology General Medicine Condyloma Acuminatum medicine.disease Genital warts law.invention Sinecatechins Randomized controlled trial law medicine business Adverse effect medicine.drug |
| Zdroj: | Archives of Dermatology. 134:25 |
| ISSN: | 0003-987X |
| DOI: | 10.1001/archderm.134.1.25 |
| Popis: | Objective To compare the safety and effectiveness of 5% and 1% imiquimod cream with vehicle cream in the treatment of external anogenital warts. Design Randomized, double-blind, placebo-controlled comparison that evaluated patients for total clearance of their warts. Patients who experienced total clearance were evaluated for recurrence in a 12-week follow-up. Setting Eleven ambulatory offices, including both private physician offices and referral medical centers. Patients Three hundred eleven healthy men and women aged 18 years or older with 2 to 50 external anogenital warts were recruited from the practices of investigators, referring physicians, and advertisements. Eighty-two additional patients were screened but did not qualify. Four patients discontinued use of the medication because of adverse effects. Interventions Five percent imiquimod (Aldara) cream, 1% imiquimod cream, or vehicle cream was applied to all external warts overnight 3 times each week for 16 weeks, or until all treated warts disappeared, whichever occurred first. Main Outcome Measurements The number of patients experiencing the elimination of all baseline warts and the recurrence rate of these warts. In addition, the reduction in baseline wart area, the duration of therapy required to eliminate warts, and the frequency and severity of adverse reactions were principal measurements. Results In the intent-to-treat analysis, 54 (50%) of 109 patients who received 5% imiquimod cream, 21 (21%) of 102 of those who received 1% imiquimod cream, and 11 (11%) of 100 patients treated with vehicle cream experienced eradication of all treated baseline warts. The difference between the effectiveness of 5% imiquimod cream and the vehicle cream was statistically significant (P Conclusions Five percent imiquimod cream is an effective and safe self-administered therapy for external anogenital warts when applied 3 times a week overnight for up to 16 weeks. The recurrence rate is low. |
| Databáze: | OpenAIRE |
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