A treatment algorithm to identify therapeutic approaches for leg ulcers in patients with sickle cell disease
| Autor: | John G. Quigley, Igor A. Altman, Caterina P. Minniti, William J. Ennis, Raymond E Kleinfelder |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
business.industry
Priapism Dermatology Disease 030204 cardiovascular system & hematology medicine.disease Pulmonary hypertension Pathophysiology Pentoxifylline 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Severity of illness medicine Combined Modality Therapy Surgery business Complication Algorithm medicine.drug |
| Zdroj: | International Wound Journal. 13:1315-1324 |
| ISSN: | 1742-4801 |
| Popis: | Sickle cell leg ulcers (SCLUs) are a common complication of sickle cell disease (SCD). Patients who develop ulcers appear to have a more severe haemolysis-associated vasculopathy than individuals who do not develop them, and manifest other complications such as priapism and pulmonary hypertension. SCLUs are slow to heal and often recur, affecting both the emotional and physical well-being of patients. Here we summarise what is known about the pathophysiology of SCLUs, describe available treatment options and propose a treatment algorithm. |
| Databáze: | OpenAIRE |
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