NMR studies of the reaction of formaldehyde with the imidazole side chain of histidine: A reactive amino acid in enzyme catalysis

Autor:	Patricia Dunlop, Charles J. Martin, Mario A. Marini, Henry M. Fales, Edward A. Sokoloski
Rok vydání:	1973
Předmět:	chemistry.chemical_classification Organic Chemistry Formaldehyde food and beverages Ring (chemistry) Biochemistry Combinatorial chemistry Amino acid Enzyme catalysis chemistry.chemical_compound Enzyme chemistry Drug Discovery Side chain Organic chemistry Imidazole Molecular Biology Histidine
Zdroj:	Bioorganic Chemistry. 2:235-247
ISSN:	0045-2068
DOI:	10.1016/0045-2068(73)90026-6
Popis:	The reaction of imidazole and imidazole derivatives with formaldehyde can be demonstrated with NMR techniques. The results show that only one nitrogen of the imidazole ring reacts to form a N-hydroxymethyl derivative in alkaline solution. Under acidic conditions both nitrogen positions can support N-hydroxymethyl derivatives. This reaction represents a useful tool for the further investigation of enzyme mechanisms involving the imidazole nucleus.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d3dbdfbba0c4897085b4e1938e155469 https://doi.org/10.1016/0045-2068(73)90026-6 Zobrazit plný text záznamu