Effects of curcumin-/boron-based compound complexation on antioxidant and antiproliferation activity
| Autor: | Joong-Hoon Ahn, Eun Ji Kim, Hyejung Mok, Yoon Young Kang, Jun Yeong Kim |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Antioxidant Chemistry Elution medicine.medical_treatment Organic Chemistry chemistry.chemical_element General Biochemistry Genetics and Molecular Biology Absorbance 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine In vivo 030220 oncology & carcinogenesis medicine Curcumin Boron Nuclear chemistry |
| Zdroj: | Applied Biological Chemistry. 61:403-408 |
| ISSN: | 2468-0842 2468-0834 |
| Popis: | Simple and reproducible formulation strategies are needed to improve the bio-availability of curcumin. In this study, curcumin was successfully complexed with two boron-based compounds: 2-aminoethyl diphenyl borate (DPBA) and bortezomib (BTZ; Velcade®). In reverse-phase high-performance liquid chromatography, DPBA/curcumin complexes (DPBA/cur) showed delayed elution times compared to those of free curcumin. The UV–visible absorbance peak of DPBA/cur and BTZ and curcumin complexes (BTZ/cur) appeared redshifted. DPBA complexation has a negligible effect on the antioxidant and antiproliferation properties of curcumin for two types of cancer cells: MCF-7 and A549. Thus, curcumin complexation with boron-based compounds could be a method to enhance in vivo stability without loss of bioactivity (i.e., antioxidant and antiproliferation effects). |
| Databáze: | OpenAIRE |
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