| Popis: |
Background: Intermediate lesions (ILs) are challenging to treat. This study aimed to assess the impact of ILs on long-term clinical outcomes in patients with significant coronary lesions (SLs).Methods: This was a non-randomized, retrospective, single-center study. The study subjects were patients with SL (n=403, Men=249), followed up for 10 years (118.5±5.5 months), and divided into 2 groups according to the presence of IL (IL (-) and IL (+) groups with 192 and 211 patients, respectively). The primary outcome was the occurrence of major adverse cardiovascular events (MACE), which included all-cause death, myocardial infarction (MI), stroke, and revascularization (RVSC).Results: There were no significant differences in MACEs between the IL (-) and IL (+) groups (death, 7.8% vs. 12.3%; MI, 0.0% vs. 2.4%; stroke, 5.7% vs. 6.6%; and RVSC, 19.8% vs. 24.6%). However, the RVSC rate related to IL was lower (5.2% vs. 13.2%) than that related to stented lesions in all subjects. The important predictors for total MACEs in all subjects were the number of ILs and ejection fraction. The predictors of total RVSC events were IL location (right coronary artery [RCA]) and hypertension. The predictor of IL-related RVSC was the number of ILs.Conclusion: Ten-year clinical outcomes of IL were excellent and better than those of stented lesions in patients with SL. Thus, ILs can be managed with optimal medical treatment with acceptable clinical outcomes in patients with SL. The increased risk of MACE in patients with multiple ILs and ILS in the RCA should be carefully managed. |
