Rhodium(III)-Catalyzed [3+2] Annulation of 5-Aryl-2,3-dihydro-1H-pyrroles with Internal Alkynes through C(sp2)H/Alkene Functionalization

Autor:	Rui Pi, Ming Hu, Ren-Jie Song, Yuanzhi Xia, Jin-Heng Li, Yuan Yang, Ming-Bo Zhou
Rok vydání:	2014
Předmět:	chemistry.chemical_classification Annulation Hydrogen bond Alkene Aryl chemistry.chemical_element General Chemistry Ring (chemistry) Medicinal chemistry Catalysis Rhodium chemistry.chemical_compound chemistry Organic chemistry Protonolysis
Zdroj:	Angewandte Chemie International Edition. 53:11338-11341
ISSN:	1433-7851
DOI:	10.1002/anie.201407175
Popis:	This study describes a new rhodium(III)-catalyzed [3+2] annulation of 5-aryl-2,3-dihydro-1H-pyrroles with internal alkynes using a Cu(OAc)2 oxidant for building a spirocyclic ring system, which includes the functionalization of an aryl C(sp2)H bond and addition/protonolysis of an alkene CC bond. This method is applicable to a wide range of 5-aryl-2,3-dihydro-1H-pyrroles and internal alkynes, and results in the assembly of the spiro[indene-1,2′-pyrrolidine] architectures in good yields with excellent regioselectivities.
Databáze:	OpenAIRE
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