Desmiflavasides A and B: Two new bioactive pregnane glycosides from the sap of Desmidorchis flava

Autor:	Issa Al-Amri, Muhammad Adil Raees, Talat Mahmood, Ivan R. Green, Husain Yar Khan, Ahmed Al-Harrasi, Hidayat Hussain, Ghulam Abbas, Ahmed Al-Rawahi, Najeeb Ur Rehman, Ali Elyassi, Mohammed Al-Broumi
Rok vydání:	2015
Předmět:	chemistry.chemical_classification Antioxidant DPPH Stereochemistry medicine.medical_treatment Pregnane Glycoside Plant Science Biochemistry Acetylcholinesterase chemistry.chemical_compound Enzyme chemistry medicine Growth inhibition Xanthine oxidase Agronomy and Crop Science Biotechnology
Zdroj:	Phytochemistry Letters. 12:153-157
ISSN:	1874-3900
DOI:	10.1016/j.phytol.2015.03.013
Popis:	The sap from the succulent, Desmidorchis flava (N.E.Br) Meve & Liede (Apocyanaceae), provided two new pregnane glycosides named desmiflavasides A ( 1 ) and B ( 2 ) whose structures were established from 1D and 2D NMR spectroscopic techniques and mass spectromentry (ESIMS) measurements. Desmiflavaside B ( 2 ) was tested for anticancer activity and induced a 27.4% and 33.1% growth inhibition of the breast cancer cell line (MDA MB231) at a concentration of 75 μg/ml and 100 μg/ml, respectively. Desmiflavasides A ( 1 ) and B ( 2 ) were additionally evaluated for: DPPH antioxidant activity, urease enzyme inhibition as well as for xanthine oxidase enzyme, α-glucosidase enzyme and acetylcholinesterase inhibition activities. They displayed weak antioxidant and urease enzyme inhibition activities with 15% inhibition.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d3c6c05cbb52860d52f35cddf052fcb3 https://doi.org/10.1016/j.phytol.2015.03.013 Zobrazit plný text záznamu Full Text from ScienceDirect