Oligodendrocytes: Functioning in a Delicate Balance Between High Metabolic Requirements and Oxidative Damage
| Autor: | Marco T. Núñez, Alejandro D. Roth |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Myelin sheaths Central nervous system Context (language use) Biology medicine.disease_cause Oxidative damage 03 medical and health sciences Myelin 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure nervous system medicine Neuroscience 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Advances in Experimental Medicine and Biology ISBN: 9783319407623 |
| Popis: | The study of the metabolic interactions between myelinating glia and the axons they ensheath has blossomed into an area of research much akin to the elucidation of the role of astrocytes in tripartite synapses (Tsacopoulos and Magistretti in J Neurosci 16:877–885, 1996). Still, unlike astrocytes, rich in cytochrome-P450 and other anti-oxidative defense mechanisms (Minn et al. in Brain Res Brain Res Rev 16:65–82, 1991; Wilson in Can J Physiol Pharmacol. 75:1149–1163, 1997), oligodendrocytes can be easily damaged and are particularly sensitive to both hypoxia and oxidative stress, especially during their terminal differentiation phase and while generating myelin sheaths. In the present review, we will focus in the metabolic complexity of oligodendrocytes, particularly during the processes of differentiation and myelin deposition, and with a specific emphasis in the context of oxidative stress and the intricacies of the iron metabolism of the most iron-loaded cells of the central nervous system (CNS). |
| Databáze: | OpenAIRE |
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