The Extracellular Matrix-Cell Interaction in ILD
| Autor: | Chandak Upagupta, Martin Kolb, Toyoshi Yanagihara |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Lung
Chemistry Cell Interstitial lung disease Inflammation respiratory system medicine.disease behavioral disciplines and activities respiratory tract diseases Cell biology body regions Elastic recoil Extracellular matrix medicine.anatomical_structure Mechanical stability Fibrosis medicine medicine.symptom |
| DOI: | 10.1016/b978-0-08-102723-3.00021-4 |
| Popis: | Interstitial lung disease (ILD) is an umbrella term for a group of disorders characterized by lung inflammation and progressive fibrosis. The extracellular matrix (ECM) is a structural scaffold for cells, which provides mechanical stability and elastic recoil necessary for proper lung function. In fibrotic ILD, the ECM undergoes structural and biochemical changes, creating a pathological microenvironment for cells. Here we explore these changes, and how they interact with cells to facilitate progressive lung fibrosis in ILD. |
| Databáze: | OpenAIRE |
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