GABAAreceptor subtype involvement in addictive behaviour
| Autor: | Theodora Duka, Sarah L. King, Jeremy J. Lambert, David N. Stephens, Delia Belelli |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Benzodiazepine medicine.drug_class GABAA receptor Addiction media_common.quotation_subject Alcohol dependency Inhibitory neurotransmitter Nucleus accumbens Impulsivity 03 medical and health sciences Behavioral Neuroscience 030104 developmental biology 0302 clinical medicine Neurology mental disorders Genetics medicine medicine.symptom Receptor Psychology Neuroscience 030217 neurology & neurosurgery media_common |
| Zdroj: | Genes, Brain and Behavior. 16:149-184 |
| ISSN: | 1601-1848 |
| Popis: | GABAA receptors form the major class of inhibitory neurotransmitter receptors in the mammalian brain. This review sets out to summarise the evidence that variations in genes encoding GABAA receptor isoforms are associated with aspects of addictive behaviour in humans, while animal models of addictive behaviour also implicate certain subtypes of GABAA receptor. In addition to outlining the evidence for the involvement of specific subtypes in addiction, we summarise the particular contributions of these isoforms in control over the functioning of brain circuits, especially the mesolimbic system, and make a first attempt to bring together evidence from several fields to understanding potential involvement of GABAA Receptor Subtypes in addictive behaviour. While the weight of the published literature is on alcohol dependency, the underlying principles outlined are relevant across a number of different aspects of addictive behaviour. |
| Databáze: | OpenAIRE |
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