P3–217: Effect of intellectual lifestyle and Alzheimer's disease biomarkers on rate of cognitive decline: Mayo Clinic Study of Aging
| Autor: | Val J. Lowe, Ronald C. Petersen, David S. Knopman, Yonas E. Geda, Scott A. Przybelski, Brian E. Gregg, Prashanthi Vemuri, Mathew Senjem, Jeffrey L. Gunter, Mary M. Machulda, Rosebud O. Roberts, Clifford R. Jack, Timothy G. Lesnick, Michelle M. Mielke |
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| Rok vydání: | 2013 |
| Předmět: |
Gerontology
medicine.medical_specialty Higher education Epidemiology business.industry Health Policy Alzheimer's disease biomarkers Disease medicine.disease Psychiatry and Mental health Cellular and Molecular Neuroscience Developmental Neuroscience Education education medicine Dementia Neurology (clinical) Senile plaques Geriatrics and Gerontology Cognitive decline Psychiatry business Psychology Brain weight |
| Zdroj: | Alzheimer's & Dementia. 9 |
| ISSN: | 1552-5279 1552-5260 |
| DOI: | 10.1016/j.jalz.2013.05.1290 |
| Popis: | dementia when compared to the individuals with no formal education (N1⁄490). After adjustment for sociodemographics and neuropathologic features including neuritic plaques, neurofibrillary tangles, lacunar infarctions, small vessel disease, and Lewy bodies, 1-4 years of education education had an OR1⁄40.54, 95%CI 0.28-1.02; p1⁄40.06;>4 years had an OR1⁄40.38, 95%CI 0.17-0.88; p1⁄40.02. Higher brain weight was also associated to lower frequency of dementia in adjusted analysis (OR1⁄4 0.64, 95% CI: 0.49-0.85, p1⁄40.002). The interaction between education and brain weight was not related do dementia (p1⁄40.37). Conclusions: Higher education and brain weight are associated with lower frequency of dementia. Education and brain weight may represent different domains of neural reserve. |
| Databáze: | OpenAIRE |
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