| Autor: |
Ajit K Parhi, Yangsheng Sun, Hye-Yeon Sagong, Jesus Rosado-Lugo, Pratik Datta, Yongzheng Zhang, Yi Yuan |
| Rok vydání: |
2022 |
| DOI: |
10.21203/rs.3.rs-1862196/v1 |
| Popis: |
S-(3,4-dichlorobenzyl) isothiourea (A22) and mecillinam are the only known antibacterial agents that act on the rod-shape maintenance mechanism of rod-like bacteria. This makes A22 an attractive lead compound for developing antibiotics with novel mechanism of action. In this study we expanded a limited structure activity relation (SAR) study previously reported and determined the effect of fused carbocyclic and heterocyclic analogs of A22 against three Gram-negative bacteria. Also, the efflux liabilities of the analogs generated here were examined in E. coli and P. aeruginosa. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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