Dose-Dependent Minimisation of Cytogenetic Toxicity of Endosulfan(an Organochlorine Pesticide) by Vitamin C

Autor:	S. P. Sinha, Parimal Kumar Khan
Rok vydání:	1992
Předmět:	Vitamin C Ratón Organochlorine pesticide Cell Biology Plant Science Biology Pesticide Pharmacology Ascorbic acid Toxicology chemistry.chemical_compound chemistry Toxicity Genetics Animal Science and Zoology Antimutagen Endosulfan
Zdroj:	CYTOLOGIA. 57:217-221
ISSN:	1348-7019 0011-4545
Popis:	Concurrent administration for seven days of therapeutic (10mg/kg bw/day) as well as 20 and 40mg/kg bw/day doses of vitamin C (L-ascorbic acid) with sub-lethal oral dose of endosulfan to Swiss albino mice could cause significant decrease in the incidence of pesticideinduced chromosomal abnormalities in the bonemarrow cells. This effect was most pronounced at 20mg/kg bw/day dose. The pesticide alone could induce both structural as well as mitosis-disruptive types of chromosomal abnormalities, albeit the latter was not significant. The effective antimutagenic doses of vitamin C, when administered alone, failed to produce any significant genotoxic effect of their own.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d3a42184fc1aa532c97674500ab238f8 https://doi.org/10.1508/cytologia.57.217 Zobrazit plný text záznamu