Histamine H1Receptor Antagonists Facilitate Electroacupuncture Analgesia
| Autor: | Hsin-Yi Chung, Shih-Ya Hung, Jaung-Geng Lin, Sih-Ting Luo, Iona MacDonald, Yi-Hung Chen, Cheng-Hao Tu, Yu-Chen Lee |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
business.industry Electroacupuncture medicine.medical_treatment Analgesic General Medicine (+)-Naloxone Pharmacology Histamine H1 Antagonists 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine Nociception Complementary and alternative medicine chemistry Medicine Receptor Pyrilamine business 030217 neurology & neurosurgery Histamine |
| Zdroj: | The American Journal of Chinese Medicine. 46:55-68 |
| ISSN: | 1793-6853 0192-415X |
| DOI: | 10.1142/s0192415x18500039 |
| Popis: | This study investigated the influence of the histamine H1receptor antagonists, chlorpheniramine (CHL) and pyrilamine, on the analgesic effects of acupuncture in mice. Nociceptive response was evaluated by the acetic acid-induced abdominal writhe test. Electroacupuncture (EA) at bilateral ST36 reduced the manifestations of acetic acid-induced abdominal writhing, whereas needle insertion without electrostimulation had no such effect. Notably, EA treatment was not associated with any analgesic effects in mice pretreated with naloxone. Low doses of CHL (0.6[Formula: see text]mg/kg; p.o.) or pyrilamine (2.5[Formula: see text]mg/kg; i.p.) as monotherapy did not affect acetic acid-induced abdominal writhing. However, when each agent was combined with EA, acetic acid-induced abdominal writhing was reduced by a greater extent when compared with EA alone. Interestingly, the effects of CHL on acupuncture analgesia were not completely reversed by naloxone treatment. Acetic acid induced increases of phospho-p38 expression in spinal cord, as determined by immunofluorescence staining and Western blot analysis. These effects were attenuated by EA at ST36 and by low doses of histamine H1receptor antagonists, alone or in combination. Our findings show that relatively low doses of histamine H1receptor antagonists facilitate EA analgesia via non-opioid receptors. These results suggest a useful strategy for increasing the efficacy of EA analgesia in a clinical situation. |
| Databáze: | OpenAIRE |
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