Biotransformation of Oleaside A byCunninghamella echinulata
| Autor: | Qing-Xin Liu, Wei-Dong Zhang, Hui-Liang Li, Ping Wan, Min Lu, Xian-Qing Hu, Zhu-Zhen Han |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
0303 health sciences
biology 010405 organic chemistry Stereochemistry Chemistry Organic Chemistry biology.organism_classification 01 natural sciences Biochemistry Catalysis 3. Good health 0104 chemical sciences Inorganic Chemistry 03 medical and health sciences Biotransformation Drug Discovery Physical and Theoretical Chemistry Cunninghamella echinulata Human cancer 030304 developmental biology |
| Zdroj: | Helvetica Chimica Acta. 97:290-297 |
| ISSN: | 0018-019X |
| DOI: | 10.1002/hlca.201300180 |
| Popis: | Biotransformation of oleaside A (1) by Cunninghamella echinulata (ACCC 30369) was carried out to afford two products, (6R)-6-hydroxyoleaside A (2) and (7S)-7-hydroxyoleaside A (3). The structures of 2 and 3 were elucidated by extensive NMR analyses and further confirmed by single-crystal X-ray diffraction analysis. We also report herein the X-ray diffraction structure of oleaside A (1) for the first time. Compounds 1–3 were evaluated for their cytotoxic activities against the A549, HCT116, HepG2, and HL-60 human cancer cell lines. |
| Databáze: | OpenAIRE |
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