Implications of exposure to dextran-coated and uncoated iron oxide nanoparticles to developmental toxicity in zebrafish
| Autor: | Ricardo Meurer Papaléo, Giovanna Medeiros Tavares de Oliveira, Elisa Magno Nunes de Oliveira, Maurício Reis Bogo, Talita Carneiro Brandão Pereira |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Materials science Developmental toxicity Nanoparticle Bioengineering 02 engineering and technology 03 medical and health sciences chemistry.chemical_compound General Materials Science Zebrafish biology General Chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics biology.organism_classification Atomic and Molecular Physics and Optics 030104 developmental biology Dextran chemistry Nanotoxicology Apoptosis Modeling and Simulation Toxicity Biophysics 0210 nano-technology Iron oxide nanoparticles |
| Zdroj: | Journal of Nanoparticle Research. 19 |
| ISSN: | 1572-896X 1388-0764 |
| Popis: | Iron oxide nanoparticles (IONPS) have been widely investigated as a platform for a new class of multifunctional theranostic agents. They are considered biocompatible, and some formulations are already available in the market for clinical use. However, contradictory results regarding toxicity of IONPs raise a concern about the potential harm of these nanoparticles. Changes in the nanoparticle (NP) physicochemical properties or exposure media can significantly alter their behavior and, as a consequence, their toxic effects. Here, behavior and two-step RT-qPCR were employed to access the potential toxicological effects of dextran-coated IONPs (CLIO-NH2) and uncoated IONPs (UCIO) in zebrafish larvae. Animals were exposed for 7 days to NP solutions ranging from 0.1–100 μg/mL directly mixed to the system water. UCIO showed high decantation and instability in solution, altering zebrafish mortality but showing no alterations in behavior and molecular expression analysis. CLIO-NH2 exposure did not cause significant mortality or changes in hatching rate of zebrafish larvae; however, behavior and expression profiles of the group exposed to lower concentration (1 μg/mL) presented a tendency to decrease the locomotor activity and apoptotic pathway activation. |
| Databáze: | OpenAIRE |
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