ChemInform Abstract: Metal- and Base-Free Syntheses of Aryl/Alkylthioindoles by the Iodine-Induced Reductive Coupling of Aryl/Alkyl Sulfonyl Chlorides with Indoles

Autor:	Vykunthapu Narayanarao, Gullapalli Kumaraswamy, Ragam Raju
Rok vydání:	2015
Předmět:	Steric effects Sulfonyl chemistry.chemical_classification Indole test chemistry.chemical_compound chemistry Methanesulfonyl chloride Aryl Electrophile Ether General Medicine Medicinal chemistry Alkyl
Zdroj:	ChemInform. 46
ISSN:	0931-7597
DOI:	10.1002/chin.201530167
Popis:	An Iodine-catalysed process for an efficient and scalable sulfenylation protocol for indoles employing aryl-/alkyl sulfonyl chlorides has been developed. A series of sterically and electronically divergent aryl-/alkyl sulfonyl chlorides participated in the sulfenylation of C(sp2)–H bonds, resulting in a high to excellent yield of indole 3-sulfenylether molecules. It is noteworthy that indole-3-thiomethyl ether is efficiently generated with methanesulfonyl chloride as an electrophile, indicating the potential of this methodology.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d381d78a5ecdfa01d0b6de27ba48b727 https://doi.org/10.1002/chin.201530167 Zobrazit plný text záznamu Plný text