Pictet–Spengler/Palladium Catalyzed Allenylation and Carbonylation Processes

Autor:	Jin Zhang, Ronald Grigg, Mark Thornton-Pett, Macpherson David T, Selvaratnam Suganthan, William S. MacLachlan, Visuvanathar Sridharan
Rok vydání:	2000
Předmět:	organic chemicals Allene Organic Chemistry Tryptophan chemistry.chemical_element Biochemistry Combinatorial chemistry Catalysis chemistry.chemical_compound chemistry Intramolecular force Drug Discovery polycyclic compounds Azepine Carbonylation Carbon monoxide Palladium
Zdroj:	Tetrahedron. 56:6585-6594
ISSN:	0040-4020
DOI:	10.1016/s0040-4020(00)00628-1
Popis:	The tactical combination of the Pictet–Spengler reaction with Pd catalyzed reactions with allene and with carbon monoxide provides rapid access to a range of tetrahydro-β-carboline and tetrahydroisoquinoline derivatives via intramolecular trapping of intermediate π-allyl– and acyl–palladium(II) complexes by the indolic or secondary amino moieties generating fused azepine and δ-lactam derivatives. Chiral tryptophan examples are also described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d377bf029ab42840fdeede05f946094d https://doi.org/10.1016/s0040-4020(00)00628-1 Zobrazit plný text záznamu Full Text from ScienceDirect