Prostaglandin E1 inhibits T-cell proliferation and renal disease in mice
| Autor: | Alan Winkelstein, Vicki E. Kelley, S Izui, Frank J. Dixon |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
T cell
Immunology Glomerulonephritis Disease Biology medicine.disease Lymphoid hyperplasia Pathology and Forensic Medicine Peripheral chemistry.chemical_compound medicine.anatomical_structure Immune system chemistry medicine Immunology and Allergy medicine.symptom Prostaglandin E1 Beneficial effects |
| Zdroj: | Clinical Immunology and Immunopathology. 21:190-203 |
| ISSN: | 0090-1229 |
| Popis: | MRL 1 mice develop an autoimmune, lupus-like disorder characterized by massive proliferation of T cells and rapidly fatal immune complex nephritis. Prostaglandin E1 (PGE1), in pharmacologic quantities, retarded the development of this syndrome. The beneficial effects included: (1) increased lifespan, (2) prevention of peripheral T lymphoid hyperplasia, (3) preservation of T-cell mitogenic responses, (4) inhibition of immune complex-mediated glomerulonephritis, and (5) reduction in the amounts of circulating gp70-anti-gp70 immune complexes and of IgG1 and IgG2b. These studies suggest that the protective effects of PGE1 are related to the inhibition of lymphoid hyperplasia and the consequent prevention of renal disease. |
| Databáze: | OpenAIRE |
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