The role of fine excipient particles in adhesive mixtures for inhalation
| Autor: | Anders Rasmuson, Per Abrahamsson, Mohammadreza Tamadondar, Kian Salehi |
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| Rok vydání: | 2021 |
| Předmět: |
Environmental Engineering
Materials science General Chemical Engineering Mixing (process engineering) Excipient 02 engineering and technology 021001 nanoscience & nanotechnology Discrete element method 020401 chemical engineering Breakage Agglomerate medicine Particle size Adhesive 0204 chemical engineering Composite material 0210 nano-technology Dispersion (chemistry) Biotechnology medicine.drug |
| Zdroj: | AIChE Journal. 67 |
| ISSN: | 1547-5905 0001-1541 |
| Popis: | Despite the fact that adding fines improve the drug dispersion performance during inhalation, the scarcity of mechanistic insight into the formulation process, independent of the aerosolization, has kept the dispute on the underlying improvement mechanism open. We therefore simulate ternary formulations (carrier, drug, fines) in a vibrational cell to explore the mixing mechanism and the effect of particle size and loading ratio of fines on formulation performance. Results suggest that the buffer theory is a critical contributory mechanism since it curtails the carrier's collision rate and, therefore, decreases agglomerate breakage. Consequently, relatively larger drug aggregates are formed over the carrier, which eventually experiences greater detachment forces. A simple dispersion test is performed to evaluate drug detachment rate at wall-collision. An excess of cohesive fines, or using larger fines, diminishes the rotational kinetic energy of coarse particles by lumping them together. This reduces drug agglomerate breakage and leads to poor mixing. |
| Databáze: | OpenAIRE |
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