Doxorubicin Loading Capacity of MIL-100(Fe): Effect of Synthesis Conditions

Autor: Abhik Bhattacharjee, Sasidhar Gumma, Mihir Kumar Purkait
Rok vydání: 2020
Předmět:
Zdroj: Journal of Inorganic and Organometallic Polymers and Materials. 30:2366-2375
ISSN: 1574-1451
1574-1443
DOI: 10.1007/s10904-020-01456-2
Popis: A drug delivery system (DDS) enables controlled release of therapeutic agents to targeted sites by responding to environmental or external stimulus. Porous materials as drug carriers have gained attention in recent times owing to their large surface area and pore volume, tunable pore size and surface functionalization ability. Metal organic frameworks (MOFs), are a class of novel porous materials and are being widely explored for drug delivery applications. In the present work, MIL-100(Fe), an iron based MOFs is chosen as delivery agent for anticancer drug doxorubicin hydrochloride (DOX). Three MIL-100(Fe) carriers were synthesized using different reactants viz. MF (presence of HF), MNF1 (absence of HF and lower water content), MNF2 (absence of HF). It was observed that MNF1 exhibited highest mesoporosity but less crystalline than MF, while MNF2 was amorphous. The mesoporosity contributed to the highest DOX loading exhibited by MNF1. On the other hand, the loaded DOX was easily released from amorphous MNF2, due to the weaker interactions between the drug and the carrier. The results obtained in this work indicate that the synthesis route and pore structure of the carrier play a significant role in the loading and release of DOX from MIL-100(Fe) carriers.
Databáze: OpenAIRE
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