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Purpose: Anal condyloma is an epithelial proliferative lesion caused by human papillomavirus (HPV) infection. The present study analyzed the HPV types detected in HIV (＋) Korean anal condyloma using PCR-based DNA microarray. Methods: DNA was extracted from the condyloma tissue of 17 patients including 9 HIV (＋) patients (M：F=15：2, mean age 35 years, 22∼59 years). The 1st PCR was performed with a general primer on L1 region, and nested PCR on the products of the 1st PCR. PCR products were hybridized with a DNA chip. Results: Fourteen patients (9 HIV (＋), 5 HIV (?)) showed positive HPV DNA. Overall, type 6 was the most common (N=11), and type 11 (N=6), type 53 (N=3) in order. Among HIV (＋) patients, type 6 was also the most common (N=7), then type 11 (N=5) and type 53 (N=3). In contrast to the HIV (?) patients, 5 patients (55.6%) proved to have multiple infections in HIV (＋) patients (2 double, 2 triple, 1 quadruple infection). Four of 9 HIV (＋) patients (44.5%) showed co-infection with high-risk HPV. Conclusion: Multiple infection and co-infection with high-risk types are more prevalent in HIV (＋) condyloma patients compared to HIV (?) patients. HPV types on HIV (＋) male anal condyloma are similar to those detected in the Korean female uterine cervix. |
