| Autor: |
ABLO, Evrard, Sioménan COULIBALI, Tchambaga Etienne CAMARA, Bakary COULIBALY, Doumadé ZON, ACHI, Patrick Armand, Ané ADJOU |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| DOI: |
10.5281/zenodo.7142393 |
| Popis: |
To explore the antibacterial activity, a series of new 2-thioalkyl-3-nitroimidazo[1,2-a]pyridine derivatives (5a-k) were synthesized and characterized by 1H, 13C Nuclear Magnetic Resonance (NMR), and High-Resolution Mass Spectrometry (HRMS) analyses. These compounds were obtained by interaction of 2-(3-nitroimidazo[1,2-a]pyridin-2-yl)isothiouronium chloride salt 3 with functionalized alkyl chloride or bromide 4 in the presence of base. The synthesized compounds were evaluated in vitro on Gram-positive bacteria (Staphylococcus aureus ATCC 29213) and two others Gram-negative bacteria (Pseudomonas aeruginosa ATCC 27853 and Pseudomonas aeruginosa 933 C/21) by solid-state diffusion and liquid microdilution methods. None of the compounds showed any antibacterial activity on the bacteria tested. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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