Surveillance biologique des patients transplantés rénaux : vers une prévision des complications associées à l’immunosuppression ?
| Autor: | E. Seilles, Cécile Courivaud, Jamal Bamoulid, F. Garnache-Ottou, Philippe Saas, Didier Ducloux |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Pharmacology
0303 health sciences Cytopenia Leukopenia business.industry medicine.medical_treatment Pharmaceutical Science Immunosuppression medicine.disease 3. Good health Transplantation 03 medical and health sciences 0302 clinical medicine Immunosuppressive drug 030220 oncology & carcinogenesis Diabetes mellitus Immunology medicine Gene polymorphism medicine.symptom business Kidney transplantation 030304 developmental biology |
| Zdroj: | Annales Pharmaceutiques Françaises. 66:115-121 |
| ISSN: | 0003-4509 |
| DOI: | 10.1016/j.pharma.2008.03.004 |
| Popis: | While the use of nonspecific immunosuppressive drugs has significantly reduced the incidence of acute graft rejection, the benefits of such therapies on chronic rejection and overall long-term graft survival are uncertain. Persistent excessive immunosuppression after immunosuppressive drug treatment is associated with long-term toxicity including increased incidence of cancers, severe infectious complications and metabolic diseases (for example, diabetes, atherosclerosis). One of our team's aims is to identify immunological factors that can predict such toxicities. We have previously demonstrated that CD4T cell cytopenia was correlated with high risk of cancers and infections as well as atherosclerosis in renal transplant recipients. Now, we are investigating the mechanisms involved in CD4T cell cytopenia. We are also exploring how inflammation and cells from the innate immunity influence the complications associated with kidney transplantation. This was performed through the analysis of gene polymorphism on TLR-4, NOD2/CARD15 receptors and IL-6 promoter and correlation with transplantation outcome. We already correlated IL-6 promoter gene polymorphism at position -174 with new-onset diabetes after transplantation in overweight patients. Identification of gene polymorphisms or factors associated with complications after transplantation may help physicians to determine high-risk recipient profiles and optimize pre- and post-transplantation treatment strategies. |
| Databáze: | OpenAIRE |
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