Recent Advances in the Medicinal Chemistry of Liver X Receptors
| Autor: | Shaimaa S. Goher, Thomas P. Burris, Lamees Hegazy, Bahaa El-Dien M. El-Gendy, M. M. H. Arief |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.drug_class Chemistry medicine.medical_treatment Computational biology Steroid 03 medical and health sciences 030104 developmental biology Immune system Nuclear receptor Drug Discovery medicine Molecular Medicine Structure–activity relationship Retinoid Liver X receptor Receptor Transcription factor |
| Zdroj: | Journal of Medicinal Chemistry. 61:10935-10956 |
| ISSN: | 1520-4804 0022-2623 |
| DOI: | 10.1021/acs.jmedchem.8b00045 |
| Popis: | Nuclear hormone receptors represent a large family of ligand-activated transcription factors that include steroid receptors, thyroid/retinoid receptors, and orphan receptors. Among nuclear hormone receptors, the liver X receptors have emerged as very important drug targets. These receptors regulate some of the most important metabolic functions, and they were also identified as anti-inflammatory transcription factors and regulators of the immune system. The development of drugs targeting liver X receptors continues to be a challenge, but advances in our knowledge of receptor structure and function move us forward, toward achieving this goal. This review highlights the latest advances in the development of synthetic LXR modulators in the primary literature from 2013 to 2017. In this review, we place great emphasis on the structure and function of LXRs because of their essential role in the drug design process. The structure–activity relationships of the most active and promising synthetic modulators are di... |
| Databáze: | OpenAIRE |
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