Association of CTSZ rs34069356 and MC3R rs6127698 gene polymorphisms with pulmonary tuberculosis

Autor:	Mohammad Hashemi, Batool Sharifi-Mood, Abdolkarim Moazeni-Roodi, Mohammad Naderi, Mohsen Taheri, Ebrahim Eskandari-Nasab
Rok vydání:	2013
Předmět:	Pulmonary and Respiratory Medicine Mutation integumentary system business.industry Cathepsin Z medicine.disease_cause Molecular biology Infectious Diseases Polymorphism (computer science) Pulmonary tuberculosis Genotype Medicine Allele business Receptor Gene
Zdroj:	The International Journal of Tuberculosis and Lung Disease. 17:1224-1228
ISSN:	1815-7920 1027-3719 3406-9356
DOI:	10.5588/ijtld.12.0762
Popis:	OBJECTIVE To evaluate the possible association between cathepsin Z (CTSZ) rs34069356 C/T (Ala286Thr) and melanocortin-3 receptor (MC3R) rs6127698 G>T (-484 G/T) gene polymorphisms and pulmonary tuberculosis (PTB) in an Iranian sample population. DESIGN This case-control study included 150 PTB patients and 177 healthy subjects. Tetra amplification refractory mutation system-polymerase chain reaction was used to detect polymorphisms. RESULTS Our findings revealed that the MC3R rs6127698 TT genotype increased the risk of PTB compared with GG (additive model: OR 2.24, 95%CI 1.13-4.64, P = 0.021) as well as GG+GT (recessive model: OR 1.89, 95%CI 1.13-3.18, P = 0.016). The rs6127698 T allele increased the risk of PTB (OR 1.56, 95%CI 1.14-2.13, P = 0.005) compared to the G allele. The CTSZ rs34069356 polymorphism was not associated with PTB in additive-, dominant- and recessive-tested inheritance models (P > 0.05). CONCLUSION Our data suggest that MC3R rs6127698, but not CTSZ rs34069356 polymorphism, is associated with PTB in a sample Iranian population.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d34c4998f5f02b697d609752531b765b https://doi.org/10.5588/ijtld.12.0762 Zobrazit plný text záznamu