High-Pressure Liquid Chromatographic Assay of Azlocillin and Mezlocillin with an Anion-Exchange Extraction Technique

Autor: Claudine E. Fasching, Lance R. Peterson
Rok vydání: 1983
Předmět:
Zdroj: Journal of Liquid Chromatography. 6:2513-2520
ISSN: 0148-3919
DOI: 10.1080/01483918308064918
Popis: An anion-exchange column deproteination technique has been employed with the high-pressure liquid chromatographic (LC) assay for azlocillin and mezlocillin. The anionexchange extraction gave excellent (97%-99%) drug recovery. Quantitation of antibiotics using the LC method compares favorably to the traditional biological assay technique with correlation coefficients for azlocillin = 0.998 and mezlocillin = 0.988. The anion-exchange extraction provides an interference-free chromatogram which aids in the LC assay of these drugs.
Databáze: OpenAIRE