Recent Advances in Bifunctional Paramagnetic Chelates for MRI

Autor:	Giovanni B. Giovenzana, Luciano Lattuada, Roberto Negri
Rok vydání:	2017
Předmět:	chemistry.chemical_classification medicine.diagnostic_test 010405 organic chemistry Gadolinium Biomolecule chemistry.chemical_element Magnetic resonance imaging General Chemistry 010402 general chemistry Ligand (biochemistry) 01 natural sciences 0104 chemical sciences chemistry.chemical_compound Nuclear magnetic resonance chemistry medicine Moiety Chelation Molecular imaging Bifunctional
Zdroj:	Israel Journal of Chemistry. 57:825-832
ISSN:	0021-2148
Popis:	Magnetic resonance imaging (MRI) is a non-invasive diagnostic modality routinely employed in modern clinical medicine to collect images of the internal organs of the human body. Contrast agents (CA) are usually administered to patients to improve the sensitivity of this technique and nowadays these agents are gadolinium complexes. Bifunctional chelating agents (BFCAs) are dual molecules containing a multidentate ligand, able to strongly coordinate a metal ion, and a reactive moiety for conjugation purposes. With BFCAs an easy labelling of biomolecules or vectors with paramagnetic ions is possible, allowing the in vivo MRI visualization of diseases at cellular or molecular level.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d33fd8e2d38627ded222ec8fd38eb7f6 https://doi.org/10.1002/ijch.201700028 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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