Oxidative damage of brain structures in a glaucoma rat model and the protective role of lipoic acid

Autor: FERREIRA Sandra María, REIDES, Claudia Gabriela, PEVERINI, Agustina, HVOZDA ARANA, Ailen Gala, JANEZIC, Natasha, LASAGNI VITAR, Romina Mayra, BRUNZINI, Ricardo, LERNER, Fabián, LLESUY, Susana Francisca
Jazyk: angličtina
Rok vydání: 2017
DOI: 10.18143/aisanh_v5i1_3
Popis: Evidence of oxidative process was found in glaucoma brain. The purpose was to evaluate the role of lipoic acid (LA) in oxidative damage of geniculate nucleus (GN) and visual cortex (VC) in glaucoma model. Four groups of Wistar rats (n=20) were used: Glaucoma(G) rats operated by cauterized episcleral veins, glaucoma treated with LA 100 mg/kg(LG), Control(C) received a sham procedure and Control treated with LA 100 mg/kg (LC). At seven days brain were removed. Thioredoxin reductase (TRxR), glutathione reductase(GR), superoxide dismutase(SOD), protein oxidation(PO), lipid damage(TBARS) and glutathione(GSH) were evaluated. Comparing LG to G: TRxR increased 52% in GN(7.6 ±0.4 nmol/min.mg protein p
Archives of the International Society of Antioxidants in Nutrition and Health (ISANH)
Databáze: OpenAIRE