Association of rs6822844 within the KIAA1109/TENR/IL2/IL21 locus with rheumatoid arthritis in the Algerian population

Autor:	A. Boucharef, A. Abdessemed, N. Raaf, Lilya Berkani, S. Louahchi, Mohammed Ghaffor, A. Nebbab, Aicha Ladjouze-Rezig, N. Bahaz, N. Khaldoun, Reda Djidjik, Ines Allam
Rok vydání:	2016
Předmět:	0301 basic medicine education.field_of_study business.industry Immunology Population Autoantibody Case-control study Odds ratio medicine.disease Confidence interval 03 medical and health sciences 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis Rheumatoid arthritis Severity of illness Genetics medicine Immunology and Allergy SNP education business
Zdroj:	HLA. 87:160-164
ISSN:	2059-2302
DOI:	10.1111/tan.12757
Popis:	Increasing evidence suggests that the rs6822844, within KIAA1109/TENR/IL2/IL21 gene cluster on 4q27, is strongly associated with rheumatoid arthritis (RA) in the Caucasian population. The aim of this study is to investigate the possible association between the SNP rs6822844 and susceptibility to RA in the Algerian Maghreb population, and to explore the association with the clinical and immunological features of RA. The polymorphism rs6822844 was genotyped in 323 RA patients and 323 healthy individuals using the TaqMan assay. A strong association of IL2/IL21 with RA susceptibility was detected in the Algerian population [odds ratio (OR) = 2.57 (95% confidence interval (CI) 1.74-3.83), P = 10(-4) ]. Our results revealed that IL2/IL21 predisposed to disease development in both autoantibody positive and negative disease. Meanwhile, the association was stronger in RA patients with anti-cyclic citrullinated peptides (ACPA) positive than those with ACPA negative [OR = 2.30 (95% CI 1.53-3.51), P = 10(-4) and OR = 1.98 (95% CI 1.01-4.22), P = 0.037, respectively]. Moreover, our findings showed a moderate association of the rs6822844 polymorphism with disease activity (P = 0.014). This study indicates for the first time that there is a strong association between IL2/IL21 rs6822844 variant and susceptibility to RA in the Algerian population, and that this association was independent from the autoantibodies status of RA patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d33bae5959e4cd694fc27e80a27fcc2d https://doi.org/10.1111/tan.12757 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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